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Retatrutide vs Tirzepatide vs Semaglutide — Research Comparison

Published May 5, 2026

Three GLP-1 family research peptides dominate UK searches in 2026: semaglutide, tirzepatide, and retatrutide. This article compares their structures, receptor targets, and research status.

Receptor targets

  • Semaglutide — single receptor agonist (GLP-1).
  • Tirzepatide — dual receptor agonist (GIP + GLP-1).
  • Retatrutide — triple receptor agonist (GIP + GLP-1 + glucagon).

Clinical status

Semaglutide is licensed in the UK as Ozempic/Wegovy. Tirzepatide is licensed as Mounjaro. Retatrutide is investigational and remains in clinical trials. Research-grade equivalents of all three are supplied for laboratory use only.

UK research supply

UK Peptide Store stocks lab-tested research-grade semaglutide, tirzepatide, and retatrutide.

Storage and reconstitution

All three are lyophilised; reconstitute with BAC water and refrigerate. Use our calculator to plan dose volumes.